Facultad de Medicina
Universidad de los Andes



Prieto D, González C, Weber L, Realini O, Pino-Lagos K, Bendek MJ, Retamal I, Beltrán V, Riedemann JP, Espinoza F, Chaparro A. “Soluble Neuropilin-1 in gingival crevicular fluid is associated with rheumatoid arthritis: An exploratory case-control study”. J Oral Biol Craniofac Re. 2021. Doi: 10.1016/j.jobcr.2021.02.010. Download.

Prieto D, Maurer G, Sáez M, Cáceres F, Pino-Lagos K, Chaparro A. “Soluble Neuropilin-1 in gingival crevicular fluid from periodontitis patients: An exploratory cross-sectional study”. J Oral Biol Craniofac Re. 2021 Jan-Mar;11(1):84-87. Doi: 10.1016/j.jobcr.2020.11.015. Epub 2020 Nov 27. Download.


Rojas C, Campos-Mora M, Cárcamo I, Villalón N, Elhusseiny A, Contreras-Kallens P, Refisch A, Gálvez-Jirón F, Emparán I, Montoya-Riveros A, Vernal R, Pino-Lagos K. “T regulatory cells-derived extracellular vesicles and their contribution to the generation of immune tolerance”. J Leukoc Biol. 2020 Sept;108(3):813-824. Doi: 10.1002/JLB.3MR0420-533RR. Download.

Court AC, Le-Gatt A, Luz-Crawford P, Parra E, Aliaga-Tobar V, Bátiz LF, Contreras RA, Ortúzar MI, Kurte M, Elizondo-Vega R, Maracaja-Coutinho V, Pino-Lagos K, Figueroa FE, Khoury M. “Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response”. EMBO Rep. 2020 Feb 5;21(2):e48052. Doi: 10.15252/embr.201948052. Download.


Zaupa A, Byres N, Dal Zovo C, Acevedo CA, Angelopoulos I, Terraza C, Nestle N, Abarzúa-Illanes PN, Quero F, Díaz-Calderón P, Olguín Y, Akentjew TL, Wilkens CA, Padilla C, Zacconi FC, Pino-Lagos K, Blaker JJ, Khoury M, Enrione J, Acevedo JP. “Cold-adaptation of a methacrylamide gelatin towards the expansion of the biomaterial toolbox for specialized functionalities in tissue engineering”. Mater Sci Eng C Mater Biol Appl. 2019 Sep;102:373-390. Doi: 10.1016/j.msec.2019.04.020. Download.

Mauricio Campos-Mora, Pamina Contreras-Kallens, Felipe Gálvez-Jirón, Oscar Cerda and Karina Pino Lagos. “CD4+Foxp3+ T regulatory cells promote transplantation tolerance by modulating effector CD4+ T cells in a Neuropilin-1-dependent manner”. Frontiers in Immunology. 2019 10:882. Doi: 10.3389/fimmu.2019.00882. Download.


Terraza C, Fuentes R, Pino-Lagos K. “IFN-γ and IL-33 modulate mesenchymal stem cells function targeting Th1/Th17 axis in a murine skin transplantation model”. Cytokine. 2018 Sep 27;111:317- 324. doi:10.1016/j.cyto.2018.09.013. Download.

Karina Oyarce, Mauricio Campos-Mora, Tania Gajardo and Karina Pino Lagos. “Vitamin C fosters the in vivo differentiation of peripheral CD4+Foxp3- T cells into CD4+Foxp3+ regulatory T cells but impairs their ability to prolong skin allograft survival”. Front Immunol. 2018 2018 Feb 9;9:112. doi: 10.3389/fimmu.2018.00112. Download.


Javier Enrione, Karina Pino, Marzena Pepczynska, Donald I. Brown, Rina Ortiz, Elizabeth Sánchez, Cristian A. Acevedo. “A novel biomaterial based on salmon-gelatin and its in-vivo evaluation as sterile wound-dressing”. Mater Lett. 2017 In Press. Doi: 10.1016/j.matlet.2017.10.049. Download.

Tania Gajardo, Mauricio Campos and Karina Pino-Lagos. “IL-33 improves the suppressive capacity of human regulatory T cells”. Transpl Open. 2017 Vol 2 (4)1-6.Download.

Contreras-Kallens P, Terraza C, Oyarce K, Gajardo T, Campos-Mora M, Barroilhet MT, Álvarez C, Fuentes R, Figueroa F, Khoury M and Pino-Lagos K. “Mesenchymal Stem Cells and their immunosuppressive role in transplantation tolerance”. Ann NY Acad Sci. 2017. Doi: 10.1111/nyas.13364. Download.


Gajardo Carrasco T, Perez F, Terraza C, Campos-Mora M, Noelle RJ, Pino-Lagos K. “IL-33 enhances retinoic acid signaling on CD4+ T cells”. Cytokine. 2016 Sep;85:120-2. Doi: 10.1016/j.cyto.2016.06.016. Download.

Catalán D, Pino-Lagos K. Editorial: Searching for Immune Tolerance Manipulating New Molecules and Exploiting New Concepts on Lymphocyte Biology. Front Immunol. 2016 Feb 1;7:27. doi: 10.3389/fimmu.2016.00027. eCollection. Download.


Gajardo Carrasco T, Morales RA, Perez F, Terraza C, Yanez L, Campos-Mora M, Pino-Lagos K. “Alarmin’ Immunologists: IL-33 as a putative target for modulating T cell-dependent responses”. Front Immunol. 2015 Jun 2;6:232. Doi: 10.3389/fimmu.2015.00232. eCollection. Download.

Gajardo T, Morales RA, Campos-Mora M, Campos-Acuna J, Pino-Lagos K. “Exogenous interleukin-33 targets myeloid-derived suppressor cells and generates periphery-induced Foxp3+regulatory T cells in skin-transplanted mice”. Immunology. 2015 May19. Doi:10.1111/imm.12483. Download.

Javier Campos, Francisco Pérez, Edgar Narváez, Mauricio Campos-Mora, Tania Gajardo, Diego Catalán, Juan C. Aguillón and Karina Pino-Lagos. “Rapamycin-conditioned dendritic cells activated with monophosphoryl lipid-A promote allograft acceptance in vivo”. Immunotherapy. 2015;7(2):101- 110. Download.

Rodrigo A. Morales, Mauricio Campos-Mora, Tania Gajardo, Francisco Pérez, Javier Campos, Juan C. Aguillón and Karina Pino-Lagos. “Retinaldehyde dehydrogenase activity is triggered during allograft rejection and it drives Th1/Th17 cytokine production”. Immunobiology. 2015 Jun;222(6):769-774. Download.

Mauricio Campos-Mora, Rodrigo A. Morales, Tania Gajardo, Francisco Pérez, Javier Campos, Diego Catalán, Juan C. Aguillón and Karina Pino-Lagos. “Neuropilin-1+ regulatory T cells promote skin allograft survival and modulate effector CD4+ T cells phenotypic signature”. Immunology and Cell Biology. 2015 Feb;93(2):113-119. Download.


Mauricio Campos-Mora, Rodrigo A. Morales, Tania Gajardo, Diego Catalan and Karina Pino- Lagos. “Neuropilin-1 in transplantation tolerance”. Front Immunol. 2013 Nov 25;4:405. Download.

Paulina Garcia-Gonzalez, Rodrigo Morales, Lorena Hoyos, Jaxaira Maggi, Javier Campos, Barbara Pesce, David Garate, Milton Larrondo, Rodrigo Gonzalez, Lilian Soto, Veronica Ramos, Pia Tobar, Maria C Molina, Karina Pino-Lagos, Diego Catalan and Juan C Aguillon. “A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that display a potent migratory capacity to lymphoid chemokines”. Journal of Translational Medicine 2013. Vol 11:128. Download.


Guo Y, Pino-Lagos K, Ahonen CA, Bennett KA, Wang J, Napoli JL, Blomhoff R, Sockanathan S, Chandraratna RA, Dmitrovsky E, Turk MJ, Noelle RJ. “A retinoic-acid rich tumor microenvironment provides clonal survival cues for tumor-specific CD8+ T cells”. Cancer Research 2012. Vol 72(20):5230-9. Download.


De Vries VC, Pino-Lagos K, Nowak EC, Bennett KA, Oliva C and Noelle RJ. “ Mast cells condition dendritic cells to mediate allograft tolerance”. Immunity 2011. Vol 35(4):550-61. Download.

Pino-Lagos K, Guo Y, Brown Ch, Bennett KA, De Vries V, Nowak E, LaMantia AS, Blomhoff R, Sockanathan S, Chandraratna R, Dmitrovsky E and Noelle RJ. “A Retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity”. J Exp Med 2011. Vol 208(9):1767-75. Download.


Pino-Lagos K, Michea P, Sauma D, Alba A, Morales J, Bono MR, Fierro A and Rosemblatt M. “Cyclosporin A-treated dendritic cells may affect the outcome of organ transplantation by decreasing CD4+CD25+ regulatory T cell proliferation”. Biological Research 2010. Vol 43: 333-37. Download.

Pino-Lagos K, Guo Y and Noelle RJ. “Retinoic Acid: A key player in immunity”. BioFactors. 2010. Aug; 27. Download.


de Vries VC, Pino-Lagos K, Elgueta R, Noelle RJ. “The enigmatic role of mast cells in dominant tolerance”. Curr Opin Organ Transplant. 2009. Aug; 14 (4):332-7. Download.

Mucida D, Pino-Lagos K, Kim G, Nowak E, Benson MJ, Kronenberg M, Noelle RJ, Cheroutre H. “Retinoic acid can directly promote TGF-b-mediated Foxp 3(+) Treg cell conversion of naïve T cells”. Immunity. 2009 Apr 17;30 (4):471-2. Download.


Pino-Lagos K, Benson MJ, Noelle RJ. Retinoic acid in the immune system. Ann N Y Acad Sci. 2008 Nov;1143:170-87. Download.

Wang L, Pino-Lagos K, de Vries VC, Guleria I, Sayegh MH, Noelle RJ. Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells. Proc Natl Acad U S A. 2008 Jul 8; 105 (27):9331-6. Download.


Benson MJ, Pino-Lagos K, Rosemblatt M, Noelle RJ. All-trans retinoic acid mediates enhanced Treg cell growth, differentiation and gut homing in the face of high levels of co-stimulation. J Exp Med. 2007 Aug 6;204 (8):1765-74. Download.

Bono MR, Elgueta R, Sauma D, Pino K, Osorio F, Michea P, Fierro A, Rosemblatt M. The essential role of chemokines in the selective regulation of lymphocyte homing. Cytokine Growth Factor Rev. 2007 Feb-Apr;18 (1-2):33-43. Download.


Lu LF, Lind EF, Gondek DC, Bennet KA, Gleeson MW, Pino-Lagos K, Scott ZA, Coyle AJ, Reed JL, Van Snick J, Strom TB, Zheng XX, Noelle RJ. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature. 2006 Aug 31;442 (7106):997-1002. Download